Abalonase® is a purified Beta-glucuronidase formula that has been designed to quickly hydrolyze conjugated drug metabolites in human samples within minutes. This novel solution is helping laboratories from all around the world to achieve higher and faster recoveries, increase throughput, reduce sample preparation times, getting cleaner results and protecting their columns and equipment.
CLEAN, Rapid and RELIABLE.
Clean and Pure.
Shown from left to right: abalonase® purified Beta-glucuronidase formula, BetaGluc 100™ and Red Abalone Beta-Glucuronidase enzyme from another company.
Produced under a propietary method on our dedicated production facility, abalonase® is a clean and pure Beta-glucuronidase formula intended to deconjugate drug metabolites as no other enzymatic or chemical method currently can.
Use abalonase® to achieve high specificity separation, liberate from unwanted matrix effects and protect your lab's precious equipment and columns.
Reduce equipment maintenance, cleaning and column replacing using abalonase® purified Beta-glucuronidase formula. Change now and start reducing costs and painful process pauses.
Unlike other enzyme preparations, abalonase® is free of enzymes that can convert and degrade drug metabolites of interest including deacetylases, 3-beta-hydroxysteroid, NAD Oxydoreductase and 3-oxosteroid-5-4-ene-isomerase. Say goodbye to 6-AM conversion and steroids transformation.
0 to 100 within minutes, not hours.
All test run at 65ºC, with the included rapid hydrolysis buffer.
Time is always scarce and you know it. Abalonase® can deconjugate glucuronidated drug metabolites within minutes of incubation.
We have thoroughly validated abalonase® Beta-glucuronidase formula on all relevant drug types and with all detection and quantitation technologies including immunoassay techniques, LC/MS/MS and GC/MS.
Abalonase® performance and results are consistent within different human sample sources including urine, blood, meconium and saliva.
Due to its performance and purity abalonase® is the best partner for dilute and shoot analysis method.
All tests run at room temperature.
Unrivaled performance in High-Throughput Screening
Abalonase® can be used for real time and room temperature hydrolysis for high-throughput drug screening applications.
Within only minutes from being applied, abalonase® can deconjugate the most toughest metabolites to hydrolyze including those of mayor interest as benzodiazepines, opioids, cannabinoids, synthetic cannabinoids and steroids.
Abalonase® has already been integrated to several screening and confirmation processes.
Abalonase® + is designed for deconjugation of both glucuronidated and sulfated metabolites. The original abalonase® formula is enriched with 4 arylsulfatases making it ideal for the hydrolysis of steroids metabolites which are well known for commonly having greater sulphate conjugation during phase II metabolism than other drug classes.
Abalonase® +, as same as abalonase®, is free of enzymes that can convert and degrade drug metabolites of interest including deacetylases, 3-beta-hydroxysteroid, NAD Oxydoreductase and 3-oxosteroid-5-4-ene-isomerase.
Rapid hydrolysis Buffer included in every order.
Every abalonase® and abalonase® + purified Beta-glucuronidase formulas comes with a rapid hydrolysis buffer to be used at your convenience.
With this buffer, abalonase® and abalonase® + purified Beta-glucuronidase formulas will achieve their maximum performance and will reduce significantly preparation times, use of reagents and errors.
Need process integration or bulk quantities?
Let our team of experts help you integrate your current process with abalonase® and abalonase® +. We can provide your laboratory with our purified Beta-glucuronidase formula in various sizes and formats in order to satisfy your needs. Contact us for more information.
We would love to have you as a customer!
For sales, quoting and technical support within the US please contact UCT, our exclusive distributor for abalonase®:
United Chemical Technologies
UCT, Inc.
2731 Bartram Road
Bristol, PA 19007
Toll Free: 800 385 3153
Phone: 215 781 9255
Technical Specifications
SKU: ABALONASE
Form: Clear aqueous solution.
Volumes: 25ml, 50ml and 100ml.
β-Glucuronidase activity: > 50,000 units/ml (Phenolphthalein-β-D-glucuronide as substrate), > 20,000,000 units/g protein.
Sulfatase activity: none.
Storage Temperature: +4 to +8ºC.
SKU: ABALONASE-PLUS
Form: Clear aqueous solution.
Volumes: 25ml, 50ml and 100ml.
β-Glucuronidase activity: > 50,000 units/ml (Phenolphthalein-β-D-glucuronide as substrate), > 20,000,000 units/g protein.
Sulfatase activity: > 400 U/ml.
Storage Temperature: +4 to +8ºC.